Busch R, Doebele R C, Patil N S, Pashine A, Mellins E D
Department of Pediatrics, Stanford University Medical Center, Stanford, CA 94305-5208, USA.
Curr Opin Immunol. 2000 Feb;12(1):99-106. doi: 10.1016/s0952-7915(99)00057-6.
Accessory molecules, such as HLA-DM and invariant chain, modulate the ligands bound to MHC class II molecules in antigen-presenting cells. Recent investigations, including gene targeting experiments, have shed light on the functions of these molecules, their mechanisms of action, interactions with class II molecules, and the relationships with associated molecules such as tetraspanins and HLA-DO.
辅助分子，如HLA-DM和恒定链，可调节抗原呈递细胞中与MHC II类分子结合的配体。包括基因靶向实验在内的近期研究，已阐明了这些分子的功能、作用机制、与II类分子的相互作用，以及与四跨膜蛋白和HLA-DO等相关分子的关系。
