Van Campenhout J, Blanchet P, Beauregard H, Papas S
Fertil Steril. 1977 Jul;28(7):728-32. doi: 10.1016/s0015-0282(16)42673-7.
Clinical aspects and the incidence of the various underlying etiologic factors were studied in 86 patients with post-oral contraceptive amenorrhea. Patients were divided into two groups according to the presence or absence of detectable galactorrhea. Group I was composed of 55 amenorrheic patients without detectable galactorrhea and group II included 31 patients with amenorrhea associated with galactorrhea. Both groups were comparable for age, gravidity, duration of intake of oral contraceptives, and duration of amenorrhea. The incidence of previous oligomenorrhea and late menarche was high in both groups. The most striking difference between the two groups was in the incidence of pituitary prolactin-secreting tumor--32% among patients with galactorrhea and less than 2% among patients without galactorrhea. Identification of galactorrhea and accurate diagnosis of its causes are mandatory for successful management of postpill amenorrhea.
对86例口服避孕药后闭经患者的临床情况及各种潜在病因的发生率进行了研究。根据是否可检测到溢乳将患者分为两组。第一组由55例无可检测到溢乳的闭经患者组成，第二组包括31例伴有溢乳的闭经患者。两组在年龄、妊娠次数、口服避孕药服用时间和闭经时间方面具有可比性。两组既往月经过少和初潮延迟的发生率都很高。两组之间最显著的差异在于垂体泌乳素分泌瘤的发生率——有溢乳的患者中为32%，无溢乳的患者中不到2%。识别溢乳并准确诊断其病因是成功治疗避孕药后闭经的必要条件。
