Keye W R, Chang R J, Wilson C B, Jaffe R B
JAMA. 1980 Sep 19;244(12):1329-32. doi: 10.1001/jama.244.12.1329.
Hypocycloidal tomograms of the sella turcica and serum prolactin concentrations were obtained in 146 women with amenorrhea, galactorrhea, or both to diagnose prolactin-secreting pituitary adenomas. Findings suggesting an adenoma, ie, abnormal tomogram and elevated serum prolactin concentration, were found in 24.6% (16/65) of previously unscreened patients and 59.2% (48/81) of prescreened patients. The combination of an abnormal tomogram and elevated prolactin level was relatively specific for an adenoma, as 91% (42/46) of women with these findings who underwent surgery had histologically confirmed tumors. Tumors occurred in women from 15 to 45 years of age, with amenorrhea or galactorrhea ranging from less than six months to more than 20 years in duration. Some women in this series also had obesity, rapid weight loss, polycystic ovarian syndrome, amenorrhea following discontinuance of oral contraceptive use, or emotional stress.
对146例患有闭经、溢乳或两者皆有的女性进行了蝶鞍的摆线体层摄影和血清催乳素浓度检测，以诊断分泌催乳素的垂体腺瘤。在先前未筛查的患者中，24.6%（16/65）发现提示腺瘤的结果，即体层摄影异常和血清催乳素浓度升高；在预先筛查的患者中，这一比例为59.2%（48/81）。体层摄影异常和催乳素水平升高的组合对腺瘤具有相对特异性，因为有这些表现且接受手术的女性中，91%（42/46）经组织学证实患有肿瘤。肿瘤发生在15至45岁的女性中，闭经或溢乳持续时间从不到6个月至超过20年不等。该系列中的一些女性还伴有肥胖、体重快速下降、多囊卵巢综合征、停用口服避孕药后闭经或情绪应激。
