Taylor R
Department of Medicine, Royal Victoria Infirmary, Newcastle upon Tyne, UK.
QJM. 1996 Feb;89(2):103-7. doi: 10.1093/qjmed/89.2.103.
Hyperemesis gravidarum causes uncontrollable vomiting, severe dehydration and muscle wasting in pregnancy and usually requires weeks or months of intravenous fluid therapy. A consecutive series of 7 women with hyperemesis gravidarum were treated with high-dose steroid therapy. Vomiting stopped within 3 h of the first dose of intravenous hydrocortisone in all patients. Maintainence oral prednisolone therapy in doses up to 45 mg/day permitted discharge from hospital within days, resumption of normal eating, reversal of muscle wasting and regain of lost weight (mean loss from prepregnant weight 10.5 +/- 4.3 kg). Prednisolone in doses of 15 mg/day or more was required for 10.6 +/- 4.7 (range 6-20) weeks. High-dose prednisolone therapy is effective in suppressing symptoms of intractable hyperemesis gravidarum and allowing normal maternal nutrition.
妊娠剧吐会导致孕期出现无法控制的呕吐、严重脱水和肌肉消耗，通常需要数周或数月的静脉补液治疗。对连续7例妊娠剧吐患者进行了大剂量类固醇治疗。所有患者在静脉注射第一剂氢化可的松后3小时内呕吐停止。维持口服泼尼松龙治疗，剂量高达45毫克/天，数天内即可出院，恢复正常饮食，肌肉消耗逆转，体重恢复（较孕前体重平均减轻10.5±4.3千克）。需要15毫克/天或更高剂量的泼尼松龙治疗10.6±4.7（范围6 - 20）周。大剂量泼尼松龙治疗可有效抑制妊娠剧吐的症状，并保证母体正常营养。
