Mumford D M, McCauley M J, Black D, Sung J S, McCormick N, Gordon H L, Ansbacher R
Fertil Steril. 1977 Jul;28(7):749-54.
Seventy-five men undergoing vasectomy were tested by radial immunodiffusion assay prevasectomy and at 6 weeks and 3, 6, and 12 months postvasectomy for possible changes in serum immunoglobulin (Ig) levels. No significant changes occurred when the results were analyzed on a group basis per time period. However, when each individual's prevasectomy Ig level was considered as his norm, significant changes appeared to occur in serum IgG levels at 6 weeks, 6 months, and 12 months postvasectomy; in serum IgM levels at 6 weeks; but not, to date, in serum IgA levels. Seasonal, environmental, and infectious factors do not seem to be associated with the changes found. No significant seminal Ig changes have been demonstrated. Consideration of these findings and implications for possible immunopathology are briefly discussed.
对75名接受输精管切除术的男性在输精管切除术前以及术后6周、3个月、6个月和12个月进行了放射免疫扩散测定，以检测血清免疫球蛋白（Ig）水平是否可能发生变化。按时间段对结果进行分组分析时，未出现显著变化。然而，当将每个个体输精管切除术前的Ig水平视为其正常水平时，输精管切除术后6周、6个月和12个月血清IgG水平似乎出现了显著变化；术后6周血清IgM水平出现显著变化；但迄今为止，血清IgA水平未出现显著变化。季节性、环境和感染因素似乎与所发现的变化无关。尚未证明精液Ig有显著变化。本文简要讨论了这些发现及其对可能的免疫病理学的影响。
