Hryncewicz C L, Koberda M, Konkowski M S
Baxter Healthcare Corporation, Round Lake, IL 60073, USA.
J Pharm Biomed Anal. 1996 Feb;14(4):429-34. doi: 10.1016/0731-7085(95)01622-8.
The spectrophotometric test for 5-hydroxymethylfurfural and related substances, which is included in multiple compendial monographs for dextrose-containing injections, was modified to eliminate interference of bisulfite anion. Experimental formulations containing heparin or dopamine hydrochloride were used in this study. The modified assay was shown to be accurate, precise and rugged. With an appropriate standard, the method can be used to measure 5-HMF in solutions with an approximate quantitation limit of 0.06 ppm.
用于5-羟甲基糠醛及相关物质的分光光度法检测包含在多个含葡萄糖注射液的药典专论中，该方法进行了修改以消除亚硫酸氢根阴离子的干扰。本研究使用了含有肝素或盐酸多巴胺的实验制剂。结果表明，修改后的检测方法准确、精密且耐用。采用合适的标准品时，该方法可用于测定溶液中的5-羟甲基糠醛，其近似定量限为0.06 ppm。
