Hofman P, Colas P, Manie S, Beck A, D'Andrea L
Laboratoire d'Anatomie Pathologique, Hopital Pasteur, Paris.
Arch Anat Cytol Pathol. 1995;43(5-6):309-24.
Among the cellular adhesion molecules, the integrin family, more particularly the VLA (Very late antigen) integrins, is currently the subject of numerous investigations in pathology. These integrins are involved in cell-cell contact or cell-matrix adhesions. During neoplastic diseases, cellular expression of integrins changes and a study of the modifications could allow a new etiopathogenic approach carcinogenesis and metastatic phenomena. New prognostic factors may be defined in tumor pathology. We describe the general structure of integrins and the mechanisms of their binding with matricial ligands and with cytoskeleton. The expression of VLA integrins and the alpha6beta4 heterodimer on normal and neoplastic human tissues is then described. Finally, we describe the involvement of these proteins in tumor progression and tissue invasion.
在细胞黏附分子中，整合素家族，尤其是VLA（极晚期抗原）整合素，目前是病理学众多研究的主题。这些整合素参与细胞间接触或细胞与基质的黏附。在肿瘤性疾病中，整合素的细胞表达会发生变化，对这些变化的研究可能会为肿瘤发生和转移现象提供一种新的病因学研究方法。肿瘤病理学中可能会定义新的预后因素。我们描述了整合素的一般结构及其与基质配体和细胞骨架结合的机制。然后描述了VLA整合素和α6β4异二聚体在正常和肿瘤性人体组织上的表达。最后，我们描述了这些蛋白质在肿瘤进展和组织侵袭中的作用。
