Rogerson S J, Beck H P, Al-Yaman F, Currie B, Alpers M P, Brown G V
Walter and Eliza Hall Institute of Medical Research, P. O. Royal Melbourne Hospital, Victoria, Australia.
Trans R Soc Trop Med Hyg. 1996 Jan-Feb;90(1):80-4. doi: 10.1016/s0035-9203(96)90487-3.
People living in areas endemic for Plasmodium falciparum develop humoral responses which may contribute to protection against clinical disease but the specificity of such protective antibody responses remains to be defined. Antibodies disrupting erythrocyte rosettes have been associated with protection against cerebral malaria, and antibodies agglutinating infected erythrocytes with reduced episodes of clinical disease. We have studied the capacity of serum from Papua New Guinean adults and children with a spectrum of malaria exposure, including children and adults at the time of clinical disease, to disrupt erythrocyte rosettes and cause agglutination of infected erythrocytes. Using a single parasite isolate, almost all sera from adults from highly endemic areas agglutinated infected erythrocytes, and the majority disrupted rosettes, in some cases at greater titres than hitherto described. There was a correlation between rosette disruption and agglutination in highly exposed adults. Rosette disrupting antibodies were equally frequent in children with cerebral and uncomplicated malaria. Antibodies causing rosette disruption were frequent only in adults with a long history of malarial exposure. Rosette disrupting antibodies do not appear to protect Papua New Guinean children or adults against cerebral malaria.
生活在恶性疟原虫流行地区的人会产生体液免疫反应，这种反应可能有助于预防临床疾病，但这种保护性抗体反应的特异性仍有待确定。破坏红细胞玫瑰花结的抗体与预防脑型疟疾有关，而凝集感染红细胞的抗体与减少临床疾病发作有关。我们研究了来自巴布亚新几内亚不同疟疾暴露程度的成年人和儿童（包括临床疾病发作时的儿童和成年人）的血清破坏红细胞玫瑰花结和引起感染红细胞凝集的能力。使用单一寄生虫分离株，来自高度流行地区的几乎所有成年人血清都能凝集感染红细胞，并且大多数血清能破坏玫瑰花结，在某些情况下，效价比迄今报道的更高。在高度暴露的成年人中，玫瑰花结破坏与凝集之间存在相关性。在患有脑型疟疾和非复杂性疟疾的儿童中，破坏玫瑰花结的抗体出现频率相同。仅在有长期疟疾暴露史的成年人中，引起玫瑰花结破坏的抗体才较为常见。破坏玫瑰花结的抗体似乎不能保护巴布亚新几内亚的儿童或成年人预防脑型疟疾。
