Barragan A, Kremsner P G, Weiss W, Wahlgren M, Carlson J
Microbiology and Tumor Biology Center, Karolinska Institutet, Swedish Institute for Infectious Disease Control, Stockholm Sweden; Department of Parasitology, Institute of Tropical Medicine, University of Tübingen, Tübingen, Germany.
Infect Immun. 1998 Oct;66(10):4783-7. doi: 10.1128/IAI.66.10.4783-4787.1998.
In this report, we show an age-related buildup of agglutinating activity as well as serum activity against rosette formation in children living in areas of Kenya and Gabon where malaria is endemic. Sera from Kenyans in general exhibited a stronger and wider immune response toward the epitopes, probably reflecting a difference in transmission patterns between the two areas. Thus, our results indicate that repeated malaria attacks in areas of endemicity, and consequently exposure to different isolate-specific antigens, will elicit an antibody-mediated response eventually enabling recognition of the majority of rosetting and agglutinating antigens. The correlation between antirosetting and agglutinating capacity was poor in individual cases, indicating that the rosetting epitopes are only a minor part of the highly diverse surface-exposed antigens (mainly PfEMP1) on the surface of parasitized erythrocytes toward which antibodies may react. These data together with our previous findings that the protection against cerebral malaria correlates with presence of antirosetting antibodies shed new light on our understanding of the gradual acquisition of immunity toward severe complications of malarial infection which children reared in areas of endemicity attain.
在本报告中，我们展示了在肯尼亚和加蓬疟疾流行地区生活的儿童中，与年龄相关的凝集活性以及抗玫瑰花结形成的血清活性的积累。一般来说，肯尼亚人的血清对这些表位表现出更强、更广泛的免疫反应，这可能反映了这两个地区传播模式的差异。因此，我们的结果表明，在流行地区反复遭受疟疾攻击，并因此接触不同的分离株特异性抗原，将引发抗体介导的反应，最终能够识别大多数玫瑰花结和凝集抗原。在个体病例中，抗玫瑰花结能力与凝集能力之间的相关性较差，这表明玫瑰花结表位只是被寄生红细胞表面高度多样化的表面暴露抗原（主要是PfEMP1）的一小部分，抗体可能会与之发生反应。这些数据以及我们之前的发现，即对脑型疟疾的保护作用与抗玫瑰花结抗体的存在相关，为我们理解在流行地区成长的儿童对疟疾感染严重并发症逐渐获得免疫力提供了新的线索。
