Sarker S K, Tierney P, Patel K S, Fisher C, Coleman D V
Cytopathology and Cytogenetics Unit, St Mary's Hospital Medical School, London.
J Laryngol Otol. 1996 Mar;110(3):237-9. doi: 10.1017/s0022215100133298.
Ploidy status of squamous cell carcinomas of the head and neck (SCCHN) from primary and recurrent tonsillar and tongue lesions has not been compared using image cytometry. We have measured and compared the DNA indices in 41 cases. There were 29 tongue SCCHN, 20/29 were primary and 9/29 were recurrent. Mean DNA index (DI) was 1.19 (range 0.70-1.81) and 1.28 (range 0.79-1.94) respectively. There were 12 tonsillar cases, 10/12 primary and two out of 12 recurrent. Mean DI was 0.84 (range 0.57-1.09) and 1.00 (range 0.98-1.02) respectively. Mean DNA indices of both primary carcinomas were lower than the mean DNA indices of the recurrent carcinomas. This difference between the two groups may be a reflection of their tumour biology. However, since our study is small no definite conclusions can be made at this stage. We aim in the future to evaluate the prognostic role of DNA indices of patients with paired primary and recurrent SCCHN. This may be of clinical value and improve the treatment modalities available to this group.
尚未使用图像细胞术比较原发性和复发性扁桃体及舌部病变的头颈部鳞状细胞癌（SCCHN）的倍性状态。我们测量并比较了41例患者的DNA指数。其中有29例舌部SCCHN，20例为原发性，9例为复发性。原发性和复发性舌部SCCHN的平均DNA指数（DI）分别为1.19（范围0.70 - 1.81）和1.28（范围0.79 - 1.94）。有12例扁桃体病例，10例为原发性，2例为复发性。原发性和复发性扁桃体病例的平均DI分别为0.84（范围0.57 - 1.09）和1.00（范围0.98 - 1.02）。原发性癌的平均DNA指数均低于复发性癌的平均DNA指数。两组之间的这种差异可能反映了它们的肿瘤生物学特性。然而，由于我们的研究规模较小，现阶段无法得出明确结论。我们未来的目标是评估原发性和复发性配对SCCHN患者DNA指数的预后作用。这可能具有临床价值，并改善该组患者可用的治疗方式。
