Cooke L D, Cooke T G, Forster G, MacDonald D G, Robertson A G, Soutar D S
Department of Surgery, Glasgow Royal Infirmary, UK.
Clin Otolaryngol Allied Sci. 1994 Apr;19(2):131-4. doi: 10.1111/j.1365-2273.1994.tb01196.x.
Cellular DNA content has been found to be an important prognostic factor in many human tumours, yet within the head and neck region few studies have examined its effect on survival and in those that have, findings differ. Eighty-one consecutive patients with squamous carcinoma of the tongue mainly treated by surgery and post-operative radiotherapy were studied. The DNA content of archival paraffin embedded tumours was measured by flow cytometry. Fifty-seven tumours were diploid and 24 were aneuploid. There was no association between ploidy status and age, sex, tumour size or nodal status. Ploidy status was not related to survival. These findings indicate that analysis of tumour DNA content in squamous carcinoma of the tongue does not provide any additional prognostic information for the individual patient.
细胞DNA含量已被发现是许多人类肿瘤中的一个重要预后因素，然而在头颈部区域，很少有研究考察其对生存率的影响，而且即便有研究，结果也不尽相同。我们对81例主要接受手术及术后放疗的舌鳞状细胞癌患者进行了连续研究。通过流式细胞术测量存档石蜡包埋肿瘤的DNA含量。57个肿瘤为二倍体，24个为非整倍体。倍体状态与年龄、性别、肿瘤大小或淋巴结状态之间无关联。倍体状态与生存率无关。这些发现表明，对舌鳞状细胞癌肿瘤DNA含量的分析并不能为个体患者提供任何额外的预后信息。
