Kurdy N M, Weiss J B, Bate A
Department of Orthopaedics, University of Manchester, Salford, UK.
Injury. 1996 Mar;27(2):143-5. doi: 10.1016/0020-1383(95)00169-7.
The early vascular response is essential for the normal progress of fracture healing and fracture site blood flow has been shown to reach a peak in the first two weeks after injury. Angiogenesis is an important step in this response as new vessel formation is necessary to vascularize the fracture haematoma and the fracture gap. Changes in serum levels of a low molecular weight endothelial stimulating angiogenic factor (ESAF) have been previously reported in a group of four patients with tibial fractures. In this group, ESAF levels were measured on three occasions only and at different time intervals. We present a more detailed profile of serum ESAF level changes in the first 14 days after the fracture.
早期血管反应对于骨折愈合的正常进程至关重要，并且已表明骨折部位的血流在损伤后的头两周达到峰值。血管生成是这一反应中的重要步骤，因为新血管形成对于骨折血肿和骨折间隙的血管化是必要的。先前有报道称，在一组4例胫骨骨折患者中，低分子量内皮刺激血管生成因子（ESAF）的血清水平发生了变化。在该组中，仅在三个不同时间间隔对ESAF水平进行了三次测量。我们展示了骨折后前14天血清ESAF水平变化的更详细情况。
