Zhang F, Gagnon R F, Richards G K, Brox A G
Department of Medicine, Montreal General Hospital, Que., Canada.
Nephron. 1996;72(4):654-61. doi: 10.1159/000188955.
Anemia is a cardinal feature of chronic renal failure (CRF) which contributes significantly to the clinical syndrome of chronic uremia. We have conducted a detailed examination of the hematological changes in CRF in the inbred mouse strain C57BL/6J. As in the human situation, CRF mice presented major hematological changes affecting primarily the erythroid cell series. Despite the presence of abundant iron stores in the bone marrow, the CRF mice developed a hypoproliferative anemia of a severity commensurate with the degree of renal impairment. The levels of circulating erythropoietin (EPO) in CRF mice were not significantly different from those in normal control littermates and were therefore inappropriately low for the degree of anemia. In contrast acutely bled control mice with normal renal function showed a significant inverse correlation between the serum EPO level and hemoglobin concentration, indicating an appropriate response to anemia. The chronic administration of recombinant human EPO raised the hemoglobin concentration of CRF mice, a therapeutic effect which was independent of the initial degree of anemia. These observations suggest that this animal model has wide applicability for the study of anemia secondary to CRF.
贫血是慢性肾衰竭（CRF）的主要特征，对慢性尿毒症的临床综合征有显著影响。我们对近交系小鼠C57BL/6J慢性肾衰竭时的血液学变化进行了详细检查。与人类情况一样，慢性肾衰竭小鼠出现了主要影响红系细胞系的血液学变化。尽管骨髓中有丰富的铁储备，但慢性肾衰竭小鼠仍出现了增生低下性贫血，其严重程度与肾功能损害程度相当。慢性肾衰竭小鼠的循环促红细胞生成素（EPO）水平与正常对照同窝小鼠相比无显著差异，因此对于贫血程度而言其水平过低。相比之下，急性失血的肾功能正常的对照小鼠血清EPO水平与血红蛋白浓度呈显著负相关，表明对贫血有适当反应。长期给予重组人促红细胞生成素可提高慢性肾衰竭小鼠的血红蛋白浓度，这种治疗效果与初始贫血程度无关。这些观察结果表明，该动物模型在研究慢性肾衰竭继发性贫血方面具有广泛的适用性。
