Pycock J F, Newcombe J R
Department of Herd Health and Reproduction, Faculty of Veterinary Medicine, University of Utrecht, The Netherlands.
Vet Rec. 1996 Apr 6;138(14):320-3. doi: 10.1136/vr.138.14.320.
The effects on pregnancy rate of three different treatments to remove intrauterine fluid were assessed in 1267 mares. The mares were mated and allocated, in strict rotation, to four treatment groups: 1) untreated controls, 2) intrauterine infusion of broad spectrum antibiotics, 3) intravenous injection of oxytocin, 4) intravenous injection of oxytocin followed by intrauterine antibiotics. The pregnancy status of the mares was determined 13 to 15 days and 27 to 30 days after ovulation by transrectal ultrasonography. The pregnancy rate of group 4 (72 per cent) was higher than that of group 2 (64 per cent, P < 0.01) or group 3 (63 per cent, P < 0.01). The pregnancy rates of groups 2 and 3 were higher than that of group 1 (56 per cent, P < 0.01). The treatment with antibiotics and oxytocin appeared to have an additive beneficial effect which suggested two different modes of action of the combination treatment, namely antibacterial activity and fluid drainage. In the untreated mares more fluid accumulated in the uterine lumen after mating, and this was the most likely reason for their lower pregnancy rate.
在1267匹母马中评估了三种不同的去除子宫内液体的治疗方法对妊娠率的影响。母马交配后，严格按照轮换方式被分配到四个治疗组：1）未治疗的对照组；2）子宫内输注广谱抗生素；3）静脉注射催产素；4）静脉注射催产素后再进行子宫内抗生素治疗。在排卵后13至15天以及27至30天，通过经直肠超声检查确定母马的妊娠状态。第4组的妊娠率（72%）高于第2组（64%，P<0.01）或第3组（63%，P<0.01）。第2组和第3组的妊娠率高于第1组（56%，P<0.01）。抗生素和催产素联合治疗似乎具有相加的有益效果，这表明联合治疗有两种不同的作用方式，即抗菌活性和液体引流。在未治疗的母马中，交配后子宫腔内积聚了更多液体，这很可能是它们妊娠率较低的原因。
