Rasch K, Schoon H A, Sieme H, Klug E
Klinik für Pferde, Tierärztliche Hochschule Hannover, Germany.
Equine Vet J. 1996 Nov;28(6):455-60. doi: 10.1111/j.2042-3306.1996.tb01617.x.
The aim of this field study was to examine the influence of the uterotonic substance oxytocin in 2 different therapeutic dosages of 15 and 25 i.u., respectively on the uterine drainage of oestrous mares and on their fertility. In addition endometrial biopsies of mares with and without intrauterine fluid accumulations around the time of ovulation were evaluated histomorphologically regarding the aetiology of susceptibility to uterine infection. A population of 59 Hanoverian Warmblood mares was used in this study. The mares were divided into Group A (mares with intrauterine fluid accumulations [n = 49]) and Group B (controls [n = 10]). Group A was further subdivided into 3 groups according to varying oxytocin administrations (none, 15 i.u., 25 i.u.). Prior to insemination, all mares were examined by rectal palpation, ultrasonography and vaginal inspection. In addition, hormone plasma concentrations were evaluated at the time of ovulation, namely oestradiol and progesterone concentrations. Endometrial biopsies were obtained from all mares. Endometrial samples for microbiological and cytological evaluation were taken from mares of Group A only. All mares were inseminated close to ovulation during the first cycle. This study shows that intravenous oxytocin treatment of mares with intrauterine fluid accumulations results in better pregnancy rates than no treatment.
本田间研究的目的是检验两种不同治疗剂量（分别为15国际单位和25国际单位）的宫缩剂催产素对发情母马子宫引流及其生育能力的影响。此外，对排卵前后有和没有子宫内积液的母马进行子宫内膜活检，从组织形态学角度评估子宫感染易感性的病因。本研究使用了59匹汉诺威温血母马。这些母马被分为A组（有子宫内积液的母马[n = 49]）和B组（对照组[n = 10]）。A组根据催产素给药情况（无、15国际单位、25国际单位）进一步细分为3组。在授精前，所有母马都通过直肠触诊、超声检查和阴道检查进行了检查。此外，在排卵时评估血浆激素浓度，即雌二醇和孕酮浓度。从所有母马身上获取子宫内膜活检样本。仅从A组母马身上采集用于微生物学和细胞学评估的子宫内膜样本。所有母马在第一个周期接近排卵时进行授精。本研究表明，对有子宫内积液的母马进行静脉注射催产素治疗比不治疗能获得更高的妊娠率。
