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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Tanaka K, Inoue T, Tezuka Y, Kikuchi T

National Research Institute of Police Science, Tokyo, Japan.

Xenobiotica. 1996 Mar;26(3):347-54. doi: 10.3109/00498259609046713.

The urinary excretion of the mercapturic acids of illudin S after oral administration to rat has been studied. 2. From lc-ms/ms analysis of methanolic extracts of lyophilized rat urine, stereo-isomeric mercapturic acids were detected. 3. The mercapturic acids excreted 3 days following administration amounted to approximately 0.39-0.73% of the administered dose. 4. In vitro glutathione conjugation of illudin S by subcellular fractions was also examined. 5. No significant increases in the formation of glutathione adducts were observed in any subcellular fractions examined.

研究了将伊鲁丁S口服给予大鼠后其硫醚氨酸的尿排泄情况。2. 通过对冻干大鼠尿液的甲醇提取物进行液相色谱-质谱/质谱分析，检测到了立体异构的硫醚氨酸。3. 给药后3天排泄的硫醚氨酸量约为给药剂量的0.39 - 0.73%。4. 还检查了伊鲁丁S在亚细胞组分中的体外谷胱甘肽结合情况。5. 在任何检查的亚细胞组分中均未观察到谷胱甘肽加合物形成的显著增加。

Tanaka K, Inoue T, Tezuka Y, Kikuchi T

National Research Institute of Police Science, Tokyo, Japan.

Xenobiotica. 1996 Mar;26(3):347-54. doi: 10.3109/00498259609046713.

The urinary excretion of the mercapturic acids of illudin S after oral administration to rat has been studied. 2. From lc-ms/ms analysis of methanolic extracts of lyophilized rat urine, stereo-isomeric mercapturic acids were detected. 3. The mercapturic acids excreted 3 days following administration amounted to approximately 0.39-0.73% of the administered dose. 4. In vitro glutathione conjugation of illudin S by subcellular fractions was also examined. 5. No significant increases in the formation of glutathione adducts were observed in any subcellular fractions examined.

研究了将伊鲁丁S口服给予大鼠后其硫醚氨酸的尿排泄情况。2. 通过对冻干大鼠尿液的甲醇提取物进行液相色谱-质谱/质谱分析，检测到了立体异构的硫醚氨酸。3. 给药后3天排泄的硫醚氨酸量约为给药剂量的0.39 - 0.73%。4. 还检查了伊鲁丁S在亚细胞组分中的体外谷胱甘肽结合情况。5. 在任何检查的亚细胞组分中均未观察到谷胱甘肽加合物形成的显著增加。