Lenzenweger M F, Dworkin R H
Laboratory of Experimental Psychopathology, Cornell University, Ithaca, New York, 14853-4401, USA.
Br J Psychiatry. 1996 Apr;168(4):432-40. doi: 10.1192/bjp.168.4.432.
This confirmatory investigation examined the underlying structure of schizophrenia phenomenology through examination of the fit of several prominent dimensional models to observed symptom data.
Confirmatory factor analysis was conducted on a correlation matrix of schizophrenia signs and symptoms derived from case history ratings of 192 individuals with schizophrenia who were the subjects in the major twin studies of schizophrenia.
Schizophrenia phenomenology appears best described by four underlying factors, namely negative symptoms, premorbid social adjustment deficits, reality distortion, and disorganisation. Of interest, the premorbid deficit dimension was directly associated with negative symptoms and disorganisation, but was inversely associated with reality distortion.
These data clearly support the multidimensionality of schizophrenia phenomenology and provide objective support for a four-factor model over other models. This four-factor model may be useful in organising existing and future data concerning the genetic, neurobiological, neurological, and psychosocial features of schizophrenia.
这项验证性研究通过检验几个突出的维度模型与观察到的症状数据的拟合度，来探究精神分裂症现象学的潜在结构。
对来自192名精神分裂症患者病史评定的精神分裂症体征和症状的相关矩阵进行验证性因素分析，这些患者是精神分裂症主要双生子研究的对象。
精神分裂症现象学似乎最好由四个潜在因素来描述，即阴性症状、病前社会适应缺陷、现实扭曲和紊乱。有趣的是，病前缺陷维度与阴性症状和紊乱直接相关，但与现实扭曲呈负相关。
这些数据明确支持精神分裂症现象学的多维性，并为四因素模型优于其他模型提供了客观支持。这个四因素模型可能有助于整理有关精神分裂症的遗传、神经生物学、神经学和心理社会特征的现有及未来数据。
