Ikemoto S, Panksepp J
Department of Psychology; Bowling Green State University, Ohio 43402, USA.
Behav Neurosci. 1996 Apr;110(2):331-45. doi: 10.1037//0735-7044.110.2.331.
Appetitive behaviors of rats were monitored in a runway situation following central infusions of neuroactive substances into brain areas implicated in electrical self-stimulation. Microinjections of the dopamine antagonist cis-flupentixol or the cholinergic antagonist atropine into the nucleus accumbens (Acb) severely reduced the approach speed and anticipatory shuttlebox activity while leaving the consumption of the 20% sucrose reward intact. Microinjections of GABA into the ventral tegmental area (VTA), pedunculopontine tegmental nucleus (PPTg), and oral pontine reticular nucleus (PnO) also severely disrupted approach without decreasing consumption. The highest doses of atropine into the VTA, PPTg, and PnO disrupted both consummatory and approach responses equally. The results indicate that modulation of various neurochemistries along the trajectory of the self-stimulation system has stronger effects on appetitive approach than consummatory motivation. The implications for understanding appetitive-approach motivation in the brain are discussed.
在将神经活性物质中枢注入与电刺激自身相关的脑区后，在跑道环境中监测大鼠的食欲行为。向伏隔核（Acb）微量注射多巴胺拮抗剂顺式氟哌噻吨或胆碱能拮抗剂阿托品，会严重降低接近速度和预期穿梭箱活动，而20%蔗糖奖励的消耗量保持不变。向腹侧被盖区（VTA）、脚桥被盖核（PPTg）和脑桥嘴侧网状核（PnO）微量注射GABA也会严重扰乱接近行为，但不降低消耗量。向VTA、PPTg和PnO注射最高剂量的阿托品会同样扰乱 consummatory 和接近反应。结果表明，沿着自我刺激系统轨迹的各种神经化学物质的调节对食欲接近的影响比对 consummatory 动机的影响更强。讨论了这些结果对理解大脑中食欲接近动机的意义。
