McCall W D, Tanner K D, Levine J D
School of Dental Medicine, SUNY, Buffalo 14214-3008, USA.
Neurosci Lett. 1996 Apr 12;208(1):45-8. doi: 10.1016/0304-3940(96)12552-0.
While the formalin test is a widely used behavioral model of tonic chemogenic pain, little is known about the responses of primary afferent nociceptors to formalin. Formalin (2.5%, 50 microliters) was injected either directly in or adjacent to the mechanical receptive fields of single C-fibers isolated from the saphenous nerve of pentobarbital-anesthetized rats. The average formalin-evoked response in C-fibers (n = 29) over time was biphasic. This biphasic time course of the C-fiber response to formalin is similar to that of the behavioral response in the awake animal and is compatible with the hypothesis that increased C-fiber activity contributes to the behavioral response in phase 2, as well as in phase 1 of the formalin test.
虽然福尔马林试验是一种广泛应用的紧张性化学源性疼痛行为模型，但对于初级传入伤害感受器对福尔马林的反应却知之甚少。将福尔马林（2.5%，50微升）直接注射到从戊巴比妥麻醉大鼠的隐神经分离出的单根C纤维的机械感受野内或其附近。随着时间的推移，C纤维（n = 29）中福尔马林诱发的平均反应是双相的。C纤维对福尔马林反应的这种双相时间进程与清醒动物的行为反应相似，并且与以下假设相符，即C纤维活动增加促成了福尔马林试验第2阶段以及第1阶段的行为反应。
