Eduardo Calore E, José Cavaliere M, Kasumi Shirata N, Araújo M F
Seção de Anatomia Patológica, Instituto de Infectologia Emílio Ribas, São Paulo/SP-Brasil.
Sao Paulo Med J. 1995 Nov-Dec;113(6):1009-11. doi: 10.1590/s1516-31801995000600002.
It has been described that women infected with the human immunodeficiency virus (HIV) present more frequent cytological abnormalities in cervicovaginal smears, generally related to infection by human papillomavirus (HPV). The present work is a study of cervicovaginal smears of 147 HIV-seropositive women submitted to routine gynecological examinations. The smears were stained by the Papanicolaou method. Cytopathic effects of HPV were found in 38 (25.8%) cases. Nuclear atypias of cervical intraepithelial neoplasia (CIN) were evident in 36 (24.5%) of these cases: 27 (18.4%), CIN I; 6 (4.0%), CIN II and 3 (2.0%) CIN III. Also 2 (1.4%) invasive carcinomas and one (0.7%) endocervical dysplasia were found. Other agents observed were: Candida sp, 19 (12.9%) cases, Gardnerella vaginalis, 19 (12.9%), Trichomonas vaginalis, 13 (8.4%), Chlamydia trachomatis 5 (3.4%), Mobiluncus sp 2 (1.4%) and Herpes simplex virus 1 (0.7%). This study emphasizes the high frequency of HPV/CIN cervicovaginal abnormalities in HIV-seropositive in our population. It is possible that immunological factors and sexual promiscuity are involved in this phenomenon.
据描述，感染人类免疫缺陷病毒（HIV）的女性宫颈阴道涂片细胞学异常更为常见，通常与人乳头瘤病毒（HPV）感染有关。本研究对147名接受常规妇科检查的HIV血清阳性女性的宫颈阴道涂片进行了分析。涂片采用巴氏染色法。在38例（25.8%）中发现了HPV的细胞病变效应。其中36例（24.5%）出现宫颈上皮内瘤变（CIN）的核异型性：27例（18.4%）为CIN I；6例（4.0%）为CIN II；3例（2.0%）为CIN III。此外，还发现2例（1.4%）浸润性癌和1例（0.7%）宫颈发育异常。观察到的其他病原体有：念珠菌属，19例（12.9%）；阴道加德纳菌，19例（12.9%）；阴道毛滴虫，13例（8.4%）；沙眼衣原体，5例（3.4%）；动弯杆菌属，2例（1.4%）；单纯疱疹病毒1型，1例（0.7%）。本研究强调了在我们的人群中，HIV血清阳性女性HPV/CIN宫颈阴道异常的高发生率。免疫因素和性乱可能与这一现象有关。
