Hepburn E R
Queensland Bioethics Centre, Brisbane, Australia.
J Med Ethics. 1996 Apr;22(2):105-10. doi: 10.1136/jme.22.2.105.
The possibility of early diagnosis and intervention is radically changed by the advent of genetic testing. The recent report of the Nuffield Council on Bioethics is timely and helpful. I have suggested, that not only the severity of the disability indicated by genetic information, and the accuracy of the data, ought to govern the approach to the implementation of screening for genetic disorders. In addition, assessment of the value of the information to those involved should be considered. The efficacy of the available therapeutic measures, combined with the prognostic data are important indices of the value of the information. These measures fall into three categories and thus indicate that three different courses of intervention may be appropriate. Three approaches to diagnosis and intervention are then outlined, drawing on the experience of various clinical initiatives.
基因检测的出现从根本上改变了早期诊断和干预的可能性。纳菲尔德生物伦理委员会最近的报告及时且很有帮助。我曾建议，不仅基因信息所表明的残疾严重程度以及数据的准确性，应该决定实施遗传疾病筛查的方法。此外，还应考虑评估该信息对相关人员的价值。现有治疗措施的疗效，结合预后数据，是该信息价值的重要指标。这些措施可分为三类，因此表明可能有三种不同的干预方式是合适的。然后借鉴各种临床举措的经验，概述了三种诊断和干预方法。
