Wu Z, Jiang X, Zhang L
Zhongshan Hospital, Shanghai Medical University.
Zhonghua Wai Ke Za Zhi. 1995 Nov;33(11):701-3.
Twenty-eight New Zealand white rabbits were randomly divided into experimental group (n = 20) and control group (n = 8). In the experimental group, the bilateral common carotid arteries were ligated, the blodd flow of right common carotid artery was reversed into the right cephalic internal jugular vein distal to the facial common vein, and the arterial and venous blood were obtained from the cerebral circulation pre and postoperatively for blood gas analysis. While in the control group, only the bilateral common carotid arteries were ligated. Both experimental group and control group were further divided equally into 4 subgroups for histological study at the 48th hour and on the 14th day after operation, cerebral angiography and ink injection on the 14th day of postoperation, and long survival observation, respectively. The results showed that all the animals survived. In the experimental group, the blood gas analysis revealed no statistical difference (P > 0.05) between pre- and postoperative. the cerebral circulation was rich and patent, and the cerebral cells were normal. In the control group, however, the cerebral blood flow was inadequate and the cerebral cells necrosed extensively. It is concluded that the adequate revascularization of ischemic brain can be created by the arteriovenous reversal.
28只新西兰白兔被随机分为实验组（n = 20）和对照组（n = 8）。实验组中，双侧颈总动脉被结扎，右侧颈总动脉血流经面总静脉远心端逆向转流至右侧头臂部颈内静脉，分别于术前、术后从脑循环获取动脉血和静脉血进行血气分析。而对照组仅结扎双侧颈总动脉。实验组和对照组又均被等分为4个亚组，分别于术后48小时、术后14天进行组织学研究，术后14天进行脑血管造影及墨汁灌注，并进行长期存活观察。结果显示所有动物均存活。实验组血气分析显示术前、术后无统计学差异（P > 0.05），脑循环丰富且通畅，脑细胞正常。然而，对照组脑血流量不足，脑细胞广泛坏死。结论：动静脉转流可实现缺血脑组织充分的血管再通。
