“活血祛瘀”汤对宫内生长受限大鼠脂质过氧化的影响

The effects of "huoxuequyu" decoction on lipid peroxidation in IUGR rats.

作者信息

Wang K F, Han Q H, Shu H Y, Ye W Y

机构信息

Institute of Integrated Traditional and Western Medicine, Tongji Hospital, Tongji Medical University, Wuhan.

出版信息

J Tongji Med Univ. 1995;15(2):117-9. doi: 10.1007/BF02887915.

DOI:10.1007/BF02887915

PMID:8731966

Abstract

The rats exposed to passive smoking were used as the animal model to further study the pathogenesis of IUGR and the effects of "Huoxuequyu" decoction. The results showed that the mean birth-weight of fetus and SOD activity of placenta and plasma in model rats were significantly reduced, and LPO levels of placenta and plasma were significantly increased. We found that the mean birth-weight and SOD activity in treated group were higher than that in model group, and LPO levels of placenta and plasma were lower in treated group than that in model group and there was no difference in SOD activity and LPO levels of placenta and plasma as well as the mean birthweight between treated group and control group, indicating that "Huoxuequyu" decoction can protect placenta and plasma against lipid peroxidation, and improve the blood circulation of uteroplacenta, thus contributing to the increase of the mean birth-weight.

摘要

将被动吸烟的大鼠作为动物模型，以进一步研究胎儿生长受限（IUGR）的发病机制及“活血化瘀”汤的作用。结果显示，模型大鼠胎儿的平均出生体重、胎盘及血浆超氧化物歧化酶（SOD）活性显著降低，胎盘及血浆脂质过氧化物（LPO）水平显著升高。我们发现，治疗组的平均出生体重和SOD活性高于模型组，治疗组胎盘及血浆LPO水平低于模型组，且治疗组与对照组胎盘及血浆SOD活性、LPO水平以及平均出生体重均无差异，表明“活血化瘀”汤可保护胎盘和血浆免受脂质过氧化损伤，改善子宫胎盘血液循环，从而有助于平均出生体重的增加。