Cai Y L, Yang R M, Xu S H
Institute of Neurology, Anhui College of TCM, Hefei.
Zhongguo Zhong Xi Yi Jie He Za Zhi. 1996 Jan;16(1):6-9.
Intelligence quotient (IQ) of 28 hepatic lenticular degeneration (HLD) patients was analysed with Wechsler Adult Intelligence Scale-revised by China (WAIS-RC) before and after two months treatment by the HLD-Relief decoction supplemented with copper-clearing drug, and the result was compared with that of 30 healthy persons for control. The results showed that the Vocable IQ (VIQ), Performance IQ(PIQ) and Full IQ(FIQ) of HLD patients were markedly lower than that of control (P < 0.005), especially in visual space disorder, which indicated that the copper ion depositing in patient's brain not only damaged neuronic motorial functions but also produced a marked effect on the patient's intelligence. After treatment, the total intelligential level including VIQ, PIQ and FIQ has been raised, particularly in PIQ in which all scores were obviously increased (P < 0.001). It was also showed that the damage of intelligence in HLD patient became more serious as the course of disease was prolonged and the early treatment facilitated the IQ level to approach the normal criterion. It indicated that the treatment with combined therapy is effective to the intelligence and extrapyramidal symptoms in HLD patients.
采用中国修订韦氏成人智力量表（WAIS-RC），对28例肝豆状核变性（HLD）患者在服用驱铜药物肝豆汤治疗2个月前后的智商进行测定，并与30名健康人作对照。结果显示，HLD患者言语智商（VIQ）、操作智商（PIQ）和总智商（FIQ）均显著低于对照组（P<0.005），尤其是在视觉空间障碍方面，提示铜离子在患者脑内沉积不仅损害神经运动功能，对患者智力也有显著影响。治疗后，患者的VIQ、PIQ和FIQ等总体智力水平均有提高，尤其是PIQ各项得分均明显增加（P<0.001）。同时发现，HLD患者智力损害随病程延长而加重，早期治疗有助于智商水平接近正常标准。提示综合治疗对HLD患者的智力及锥体外系症状有效。
