Bhavnani S M, Levin G M
SUNY Buffalo Clinical Pharmacokinetics Laboratory, Millard Fillmore Hospital, USA.
Int Clin Psychopharmacol. 1996 Mar;11(1):1-12.
We prospectively studied 64 male veteran out-patients with psychotic illnesses receiving one of six antipsychotic agents grouped by potency (low, mid, high, atypical) to determine: (1) prevalence of side effects; (2) cumulative side effect burden; and (3) relationship between side effects and patient-perceived burden. Patients were administered a questionnaire which included: (1) demographic information; (2) prevalence of 49 side effects; (3) visual analog scales (VAS) rating the severity of 10 selected side effects; and (4) overall side effect burden scale. Outcome measures included comparison of the prevalence, severity and overall burden of side effects among the potency groups (Part A); and association between side effect prevalence and burden, the correlation between severity and burden of certain side effects and demographic variables for the entire population (Part B). In Part A some unexpected similarities and differences were seen among data collected; few significant differences were found between groups. In Part B, 11 of 49 side effects (22%) were significantly associated with burden; the severity of 9 of 10 side effects (90%) and two demographic variables were significantly correlated with burden. These findings suggest that the prevalence and severity of many side effects of antipsychotic agents may affect a patient's perception of side effect-related burden. The side effect burden ratings suggest that the low-potency agents were the most burdensome, while the atypical group was the least burdensome.
我们对64名患有精神疾病的男性退伍军人门诊患者进行了前瞻性研究，这些患者正在接受六种抗精神病药物中的一种治疗，这些药物按效力（低、中、高、非典型）分组，以确定：（1）副作用的发生率；（2）累积副作用负担；以及（3）副作用与患者感知负担之间的关系。患者接受了一份问卷，其中包括：（1）人口统计学信息；（2）49种副作用的发生率；（3）视觉模拟量表（VAS）对10种选定副作用的严重程度进行评分；以及（4）总体副作用负担量表。结果指标包括比较效力组之间副作用的发生率、严重程度和总体负担（A部分）；以及整个研究人群中副作用发生率与负担之间的关联、某些副作用的严重程度与负担之间的相关性以及人口统计学变量（B部分）。在A部分，收集到的数据之间存在一些意想不到的异同；各组之间几乎没有发现显著差异。在B部分，49种副作用中有11种（22%）与负担显著相关；10种副作用中有9种（90%）的严重程度和两个人口统计学变量与负担显著相关。这些发现表明，抗精神病药物的许多副作用的发生率和严重程度可能会影响患者对副作用相关负担的感知。副作用负担评分表明，低效价药物负担最重，而非典型组负担最轻。
