Poyurovsky M, Modai I, Weizman A
Tirat Carmel Medical Health Center, Haifa, Israel.
Int Clin Psychopharmacol. 1996 Mar;11(1):61-3. doi: 10.1097/00004850-199603000-00010.
Enuresis is an adverse event of clozapine treatment. The occurrence of nocturnal functional enuresis in two schizophrenic patients during the initial phase of clozapine therapy is reported. Beneficial effect of trihexyphenidyl administration (5 mg at 21.00 h) on clozapine-induced enuresis is clearly demonstrated in one patient. Trihexyphenidyl discontinuation and subsequent readministration in this patient led to corresponding recurrence and then disappearance of enuresis. Involvement of the cholinergic system has been proposed as one of the possible pathophysiological mechanisms of clozapine-induced enuresis.
遗尿是氯氮平治疗的一种不良事件。本文报道了2例精神分裂症患者在氯氮平治疗初期出现夜间功能性遗尿的情况。在1例患者中，明确显示了服用苯海索（21:00时服用5mg）对氯氮平所致遗尿的有益作用。该患者停用苯海索后遗尿复发，再次服用后遗尿消失。胆碱能系统的参与被认为是氯氮平所致遗尿可能的病理生理机制之一。
