Hopkins K D, Lehmann E D, Jones R L, Turay R C, Gosling R G
Division of Medicine, United Medical and Dental Schools of Guy's and St. Thomas' Hospitals, University of London, U.K.
Diabetes Care. 1996 May;19(5):501-3. doi: 10.2337/diacare.19.5.501.
NIDDM is associated with stiffer arteries and an increased incidence of macrovascular disease. NIDDM has strong familial inheritance. We studied the associations of a family history of NIDDM with blood pressure-corrected aortic distensibility (Cp).
Because age is a strong determinant of arterial distensibility, we studied an age-select cohort of 67 healthy normotensive normoglycemic young adults along with fasting measurements of glucose and insulin concentrations. Cp was calculated from noninvasive Doppler ultrasound measurements of pulse wave velocity along the descending thoracoabdominal aorta.
The mean age of the subjects was 20.6 +/- 0.7 (mean +/- SD) years. A total of 22 subjects gave a positive family history of NIDDM in a parent or grandparent. Subjects with a positive family history of NIDDM had significantly less distensible (i.e., stiffer) aortas than their age- and sex-matched counterparts who gave no family history of NIDDM (Cp [dimensionless]: 0.22 +/- 0.04 vs. 0.25 +/- 0.04, P = 0.02). Subjects with a positive family history of NIDDM also had significantly higher fasting glucose (5.1 +/- 0.4 vs. 4.9 +/- 0.4 mmol/l, P = 0.009) and insulin (7.5 +/- 5.5 vs. 4.2 +/- 2.0 mU/l, P = 0.02) levels and BMIs (23.2 +/- 2.3 vs 21.1 +/- 2.5 kg/m2, P = 0.002). On multivariate regression analysis, family history of NIDDM (P = 0.03) was the only significant independent predictor of Cp.
A positive family history of NIDDM is associated with decreased aortic distensibility in early adult life. The relevance of these observations to future cardiovascular events merits further investigation.
非胰岛素依赖型糖尿病（NIDDM）与动脉僵硬度增加及大血管疾病发病率升高相关。NIDDM具有很强的家族遗传性。我们研究了NIDDM家族史与血压校正主动脉扩张性（Cp）之间的关联。
由于年龄是动脉扩张性的一个重要决定因素，我们研究了一个年龄选择性队列，其中包括67名健康的血压正常、血糖正常的年轻成年人，并对他们进行了空腹血糖和胰岛素浓度测量。Cp是根据沿降主动脉和腹主动脉的脉搏波速度的无创多普勒超声测量计算得出的。
受试者的平均年龄为20.6±0.7（平均值±标准差）岁。共有22名受试者的父母或祖父母有NIDDM家族史呈阳性。有NIDDM家族史阳性的受试者的主动脉扩张性明显低于年龄和性别匹配但无NIDDM家族史的受试者（Cp[无量纲]：0.22±0.04对0.25±0.04，P = 0.02）。有NIDDM家族史阳性的受试者的空腹血糖（5.1±0.4对4.9±0.4 mmol/l，P = 0.009）、胰岛素（7.5±5.5对4.2±2.0 mU/l，P = 0.02）水平和体重指数（BMI）（23.2±2.3对21.1±2.5 kg/m2，P = 0.002）也明显更高。在多变量回归分析中，NIDDM家族史（P = 0.03）是Cp的唯一显著独立预测因素。
NIDDM家族史阳性与成年早期主动脉扩张性降低有关。这些观察结果与未来心血管事件的相关性值得进一步研究。
