正常人红细胞中磷脂酰胆碱过氧化氢和磷脂酰乙醇胺过氧化氢水平的年龄相关变化。
Age-related change of phosphatidylcholine hydroperoxide and phosphatidylethanolamine hydroperoxide levels in normal human red blood cells.
作者信息
Miyazawa T, Suzuki T, Fujimoto K, Kinoshita M
机构信息
Department of Applied Biological Chemistry, Tohoku University, Sendai, Japan.
出版信息
Mech Ageing Dev. 1996 Mar 29;86(3):145-50. doi: 10.1016/0047-6374(95)01687-2.
The age-related occurrence of phosphatidylcholine hydroperoxide (PCOOH) and phosphatidylethanolamine hydroperoxide (PEOOH) in normal human red blood cells (RBC) was confirmed by using chemiluminescence detection-high performances liquid chromatography (CL-HPLC). The concentration (mean +/- S.D.) for the healthy young adult (22-27 of age, n = 20) was 93 +/- 17 pmol PCOOH and 121 +/- 20 pmol PEOOH/ml packed RBC, while for the aged adult (56-92 of age, n = 20) the peroxide content was significantly higher, 162 +/- 52 pmol PCOOH and 186 +/- 40 pmol PEOOH/ml packed RBC. These results indicate that oxidative stress occurs constantly on RBC, even in normal humans, and that the susceptivity significantly increases with age.
通过化学发光检测-高效液相色谱法（CL-HPLC）证实了正常人红细胞（RBC）中与年龄相关的磷脂酰胆碱氢过氧化物（PCOOH）和磷脂酰乙醇胺氢过氧化物（PEOOH）的出现情况。健康年轻成年人（年龄22 - 27岁，n = 20）的浓度（平均值±标准差）为93±17 pmol PCOOH和121±20 pmol PEOOH/毫升压积红细胞，而老年成年人（年龄56 - 92岁，n = 20）的过氧化物含量显著更高，为162±52 pmol PCOOH和186±40 pmol PEOOH/毫升压积红细胞。这些结果表明，即使在正常人中，红细胞也持续存在氧化应激，并且随着年龄增长，易感性显著增加。
Zotero 插件