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缺血再灌注损伤与挥发性麻醉剂

Ischemia-reperfusion injury and volatile anesthetics.

作者信息

Erturk Engin

机构信息

Department of Anesthesiology and Intensive Care Medicine, Faculty of Medicine, Karadeniz Technical University, 61080 Trabzon, Turkey.

出版信息

Biomed Res Int. 2014;2014:526301. doi: 10.1155/2014/526301. Epub 2014 Jan 2.

DOI:10.1155/2014/526301
PMID:24524079
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3909964/
Abstract

Ischemia-reperfusion injury (IRI) is induced as a result of reentry of the blood and oxygen to ischemic tissue. Antioxidant and some other drugs have protective effect on IRI. In many surgeries and clinical conditions IRI is counteract inevitable. Some anesthetic agents may have a protective role in this procedure. It is known that inhalational anesthetics possess protective effects against IRI. In this review the mechanism of preventive effects of volatile anesthetics and different ischemia-reperfusion models are discussed.

摘要

缺血再灌注损伤（IRI）是由于血液和氧气重新进入缺血组织而诱发的。抗氧化剂和其他一些药物对IRI具有保护作用。在许多手术和临床情况下，IRI不可避免地会产生。一些麻醉剂可能在这个过程中起到保护作用。已知吸入性麻醉剂对IRI具有保护作用。在这篇综述中，讨论了挥发性麻醉剂的预防作用机制和不同的缺血再灌注模型。

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Sevoflurane and isoflurane preconditioning provides neuroprotection by inhibition of apoptosis-related mRNA expression in a rat model of focal cerebral ischemia.七氟醚和异氟醚预处理通过抑制局灶性脑缺血大鼠模型中凋亡相关 mRNA 表达提供神经保护作用。
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