Johnson E S, Griswold C M
National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina.
Med Hypotheses. 1996 Apr;46(4):354-6. doi: 10.1016/s0306-9877(96)90186-3.
Reticuloendotheliosis virus naturally infects and cause lymphoid leukosis in chickens and turkeys. We investigated whether it can infect/transfect a variety of human cells in vitro. Successful infection and transfection were achieved with limited replication of virus. These findings, together with the knowledge that other oncogenic retroviruses of chickens and cattle, viz. The avian leukosis/sarcoma viruses and bovine leukemia virus show similar infectivity/oncogencity in vitro for humans, and the recent demonstration of antibodies to avian leukosis/sarcoma virus and reticuloendotheliosis virus in human sera, suggest that these viruses may have a role in the etiology of certain cancers in humans. There is now urgent need to investigate this, particularly because recent epidemiological studies consistently demonstrate excess of cancers in groups occupationally exposed to these viruses.
网状内皮组织增殖病病毒可自然感染鸡和火鸡并引发淋巴白血病。我们研究了它在体外能否感染/转染多种人类细胞。病毒虽复制有限，但成功实现了感染和转染。这些发现，连同鸡和牛的其他致癌逆转录病毒，即禽白血病/肉瘤病毒和牛白血病病毒在体外对人类表现出类似感染性/致癌性这一认知，以及近期在人类血清中发现针对禽白血病/肉瘤病毒和网状内皮组织增殖病病毒的抗体，表明这些病毒可能在人类某些癌症的病因学中发挥作用。现在迫切需要对此进行研究，特别是因为最近的流行病学研究一致表明，职业接触这些病毒的人群中癌症发生率过高。
