Lee Jehoon, Kim Yonggoo, Kang Chang Suk, Cho Dae Hyun, Shin Dong Hwan, Yum Young Na, Oh Jae Ho, Kim Sheen Hee, Hwang Myung Sil, Lim Chul Joo, Yang Ki Hwa, Han Kyungja
Department of Clinical Pathology, The Catholic University of Korea, Medical College, Korea.
J Korean Med Sci. 2005 Aug;20(4):603-6. doi: 10.3346/jkms.2005.20.4.603.
The bovine leukemia virus (BLV) is the causative agent of enzootic bovine leucosis. This study investigated the presence of the BLV in leukemia (179 acute lymphoblastic leukemia, 292 acute myeloid leukemia and 46 chronic myelogenous leukemia cases) and 162 lung cancer patients (139 adenocarcinoma, 23 squamous cell carcinoma) to determine if the BLV is a causative organism of leukemia and lung cancer in Koreans. A BLV infection was confirmed in human cells by PCR using a BLV-8 primer combination. All 517 cases of human leukemia and 162 lung cancer were negative for a PCR of the BLV proviral DNA. In conclusion, although meat has been imported from BLV endemic areas, the BLV infection does not appear to be the cause of human leukemia or lung cancer in Koreans. These results can be used as a control for further studies on the BLV in Koreans.
牛白血病病毒（BLV）是地方流行性牛白血病的病原体。本研究调查了白血病患者（179例急性淋巴细胞白血病、292例急性髓细胞白血病和46例慢性粒细胞白血病病例）和162例肺癌患者（139例腺癌、23例鳞状细胞癌）中BLV的存在情况，以确定BLV是否为韩国人白血病和肺癌的致病生物。通过使用BLV - 8引物组合进行PCR，在人细胞中证实了BLV感染。所有517例人类白血病病例和162例肺癌病例的BLV前病毒DNA PCR检测均为阴性。总之，尽管有从BLV流行地区进口肉类的情况，但BLV感染似乎并非韩国人患人类白血病或肺癌的原因。这些结果可作为韩国人进一步研究BLV的对照。
