Hässig A, Wen-Xi L, Stampfli K
Study Group Nutrition and Immunity, Bern, Switzerland.
Med Hypotheses. 1996 Apr;46(4):388-92. doi: 10.1016/s0306-9877(96)90192-9.
The time of re-evaluation of the role of human immunodeficiency viruses in the pathogenesis of acquired immune deficiency syndrome has now come, now that methods are available for the direct detection of human immunodeficiency viruses and for the detection of cellular anti-human immunodeficiency virus immune reactions. It has been shown that human immunodeficiency virus infections are common among anti-human immunodeficiency virus antibody negative high-risk individuals. The disease is brought under control by cellular immune reactions and the anti-human immunodeficiency virus antibody test remains negative. Apart from proof that infection with human immunodeficiency viruses has occurred, a positive result in an anti-human immunodeficiency virus-antibody test is also an indication of an independent immunosuppression state. According to the definition of the Centers of Disease Control classical acquired immune deficiency syndrome is the consequence of infection with human immunodeficiency virus in association with continuous excessive stress, such as observed in the known risk groups. At the center of the pathogenetic process is hypercortisolism-determined damage of T lymphocytes, in which insufficiency of thymus is prominent. For this reason, in our view, there are indications for shifting efforts from the prophylaxis of infection with human immunodeficiency viruses to the prophylaxis of acquired immune deficiency syndrome by reducing stress factors.
既然已有方法可用于直接检测人类免疫缺陷病毒以及检测细胞抗人类免疫缺陷病毒免疫反应，那么重新评估人类免疫缺陷病毒在获得性免疫缺陷综合征发病机制中的作用的时机已经到来。研究表明，在抗人类免疫缺陷病毒抗体阴性的高危个体中，人类免疫缺陷病毒感染很常见。疾病通过细胞免疫反应得到控制，抗人类免疫缺陷病毒抗体检测仍为阴性。除了证明已发生人类免疫缺陷病毒感染外，抗人类免疫缺陷病毒抗体检测呈阳性也是独立免疫抑制状态的一个指标。根据疾病控制中心的定义，经典的获得性免疫缺陷综合征是人类免疫缺陷病毒感染与持续过度应激共同作用的结果，如在已知的高危人群中所观察到的那样。发病过程的核心是高皮质醇血症导致的T淋巴细胞损伤，其中胸腺功能不全较为突出。因此，在我们看来，有迹象表明应将努力方向从预防人类免疫缺陷病毒感染转向通过减少应激因素来预防获得性免疫缺陷综合征。
