Wright S G, Tomkins A M, Ridley D S
Gut. 1977 May;18(5):343-50. doi: 10.1136/gut.18.5.343.
Malabsorption was present in 29 of 40 symptomatic patients with giardiasis. Twenty-three had impaired D-xylose absorption; in 20 vitamin B12 absorption was low, and 15 patients had steatorrhoea. More severe malabsorption was associated with more marked histological abnormalities. Metronidazole, 2-0 g as a single daily dose on three successive days, produced a parasitological cure rate of 91%. In contrast, the standard course of mepacrine, 100 mg thrice daily for 10 days, eradicated the parasite in only 63% of patients. Improvements in absorption and jejunal morphology followed anti-giardial treatment. Tetracycline in eight patients failed to eradicate the parasite, intestinal absorption was unaltered, and histological appearances of the jejunal mucosa often deteriorated.
40例有症状的贾第虫病患者中，29例存在吸收不良。23例D-木糖吸收受损；20例维生素B12吸收降低，15例患者有脂肪泻。更严重的吸收不良与更明显的组织学异常相关。甲硝唑，连续三天每日单次剂量2.0克，寄生虫学治愈率为91%。相比之下，标准疗程的米帕林，每日三次，每次100毫克，连用10天，仅63%的患者寄生虫被根除。抗贾第虫治疗后吸收和空肠形态有所改善。8例患者使用四环素未能根除寄生虫，肠道吸收未改变，空肠黏膜的组织学表现常恶化。
