Räsänen L, Kalimo K, Laine J, Vainio O, Kotiranta J, Pesola I
Department of Dermatology, University Hospital of Kuopio, Finland.
Br J Dermatol. 1996 Apr;134(4):673-7. doi: 10.1111/j.1365-2133.1996.tb06968.x.
Gold sodium thiosulphate (GSTS) in patch test series commonly yields positive reactions. In this study of dental patients, the clinical relevance of these positive reactions, the suitability of gold compounds as patch test materials, and value of the lymphocyte proliferation test in gold contact allergy, were evaluated. The frequency of positive patch test reactions to GSTS was 12.4% in the dental series. Fifty-two patients, only two of whom were male, were studied. Thirteen (25%) had had symptoms from jewellery or dental restorations. However, in most cases gold allergy was subclinical. A 10% aqueous solution of gold sodium thiomalate (GSTM) was almost as good as 0.5% GSTS in petrolatum as a marker of gold contact allergy, but 0.001% potassium dicyanoaurate (PDCA) yielded a high percentage of false-negative results. Seventy-three per cent of the subjects with positive patch tests to GSTS responded to gold compounds in vitro in the lymphocyte proliferation test, whereas 13 controls without gold contact sensitivity were negative. Consistent results in skin and lymphocyte proliferation tests provide support for the concept that gold salt-induced 'allergic-like' reactions are truly allergic in nature.
硫代硫酸钠金钠（GSTS）在斑贴试验系列中通常会产生阳性反应。在这项针对牙科患者的研究中，评估了这些阳性反应的临床相关性、金化合物作为斑贴试验材料的适用性以及淋巴细胞增殖试验在金接触过敏中的价值。在牙科患者系列中，对GSTS斑贴试验阳性反应的频率为12.4%。研究了52名患者，其中只有两名男性。13名（25%）患者有来自珠宝或牙科修复体的症状。然而，在大多数情况下，金过敏是亚临床的。硫代苹果酸金钠（GSTM）的10%水溶液作为金接触过敏的标志物几乎与凡士林基质中的0.5%GSTS一样好，但0.001%二氰合金酸钾（PDCA）产生了高比例的假阴性结果。对GSTS斑贴试验呈阳性的受试者中有73%在淋巴细胞增殖试验中对金化合物有体外反应，而13名无金接触敏感性的对照者为阴性。皮肤试验和淋巴细胞增殖试验结果一致，为金盐诱导的“类过敏”反应本质上是真正的过敏这一概念提供了支持。
