Ormerod L P, Horsfield N
Chest Clinic, Blackburn Royal Infirmary, UK.
Tuber Lung Dis. 1996 Feb;77(1):37-42. doi: 10.1016/s0962-8479(96)90073-8.
United Kingdom, 1978-1992.
To assess the incidence and type of reactions to antituberculosis drugs in an unselected series of patients.
All patients treated for tuberculosis had details of drug treatment, durations and side-effects requiring alteration of treatment available. The data was compiled retrospectively for 1978-1980 patients and prospectively thereafter. Analysis of drug reactions was by drug, total months drug use, by age, sex and ethnic group, and reaction type.
Of 1317 patients 67 (5.1%) had 70 reactions to antituberculosis drugs requiring modification of treatment. The frequency of drug reactions increased from 2.3% at age 0-19 to 4.6% at age 20-39, 7.1% for age 40-59 and to 8.4% for those aged 60 and over. Females had significantly higher reactions rates than males. White patients had higher reaction rates than Pakistani and Indian patients, mainly due to the average age being greater.
The drug reaction rate of 5.1% in this largely prospective study is lower than that reported in other unselected series in the UK and other countries.
英国，1978年至1992年。
评估未经挑选的一系列患者对抗结核药物的反应发生率及类型。
所有接受结核病治疗的患者均有药物治疗细节、疗程以及需要改变治疗方案的副作用信息。对1978 - 1980年的患者数据进行回顾性整理，之后进行前瞻性整理。通过药物、药物使用总月数、年龄、性别和种族以及反应类型对药物反应进行分析。
1317名患者中，67名（5.1%）出现了70次对抗结核药物的反应，需要改变治疗方案。药物反应频率从0 - 19岁的2.3%增至20 - 39岁的4.6%，40 - 59岁为7.1%，60岁及以上为8.4%。女性的反应率显著高于男性。白人患者的反应率高于巴基斯坦和印度患者，主要是因为平均年龄更大。
在这项主要为前瞻性的研究中，5.1%的药物反应率低于英国和其他国家其他未经挑选系列研究中所报告的反应率。
