Exley C, Wicks A J, Hubert R B, Birchall J D
Department of Chemistry, Keele University, Staffordshire, U.K.
J Theor Biol. 1996 Mar 7;179(1):25-31. doi: 10.1006/jtbi.1996.0044.
We have designed a laboratory bioassay to expose fish to kinetically determined differences in aluminium hydroxide solution chemistry. We have used this system to demonstrate the hitherto unexpected result of an acute aluminium toxicity in the fish at a pH of 6.5. Supporting experiments have demonstrated that the mechanism of toxicity at this pH was probably an asphyxiation brought about by aluminium-induced changes in the rheological and diffusional properties of the mucus lining of the gill epithelium.
我们设计了一种实验室生物测定方法，使鱼类暴露于动力学确定的氢氧化铝溶液化学差异中。我们利用这个系统证明了在pH值为6.5时鱼类急性铝毒性这一迄今出乎意料的结果。支持性实验表明，在这个pH值下的毒性机制可能是铝诱导鳃上皮黏液衬里的流变学和扩散特性发生变化而导致的窒息。
