Tong M C, Woo J K, van Hasselt C A
Department of Surgery, Chinese University of Hong Kong, Shatin.
J Laryngol Otol. 1996 Apr;110(4):309-14. doi: 10.1017/s0022215100133523.
Active chronic suppurative otitis media poses a management problem when patients are being considered for surgical treatment. Topical antibiotics have demonstrated varying degrees of success in the management of discharging ears. The introduction of quinolones has revived interest in these topical agents. This double-blind study compares two antibiotics, namely ofloxacin and neomycin-polymyxin B, with similar in vitro sensitivities to Gram positive and Gram negative organisms. Fifty-two patients were selected randomly and the results show that ofloxacin eardrops have marginal benefits in symptomatic improvement (89 per cent versus 79 per cent, p = 0.27) and bacterial eradication (81 per cent versus 75 per cent, p = 0.81) in active chronic suppurative otitis media. Significantly fewer patients (seven per cent versus 29 per cent, p = 0.04) in the ofloxacin group had active disease at the end of the two-week treatment. We recommend the use of ofloxacin eardrops in managing active chronic suppurative otitis media since it has high clinical efficacy, contains no steroid component and has no demonstrated risk of ototoxicity.
当考虑对慢性化脓性中耳炎患者进行手术治疗时，会出现治疗难题。局部使用抗生素在治疗耳流脓方面已显示出不同程度的成效。喹诺酮类药物的引入重新引发了人们对这些局部用药的兴趣。这项双盲研究比较了两种抗生素，即氧氟沙星和新霉素 - 多粘菌素B，它们对革兰氏阳性菌和革兰氏阴性菌的体外敏感性相似。随机选取了52名患者，结果显示，在慢性化脓性中耳炎的症状改善（89% 对79%，p = 0.27）和细菌清除（81% 对75%，p = 0.81）方面，氧氟沙星滴耳液的益处不大。在为期两周的治疗结束时，氧氟沙星组的活动性疾病患者明显较少（7% 对29%，p = 0.04）。我们建议使用氧氟沙星滴耳液来治疗慢性化脓性中耳炎，因为它具有较高的临床疗效，不含类固醇成分，且未显示出耳毒性风险。
