Liston R, Pitt M A, Banerjee A K
Department of Medicine for the Elderly, Bolton General Hospital, UK.
Postgrad Med J. 1996 Apr;72(846):221-3. doi: 10.1136/pgmj.72.846.221.
Helicobacter pylori is associated with gastritis, peptic ulcers and gastric malignancies. Little attention has been paid to the possibility that it may also have a role in the pathogenesis of reflux oesophagitis. This is especially true in elderly patients who have life-long infection and provide an ideal group to study the mucosal changes associated with the organism. The aim of this study was to determine if H pylori is associated with reflux oesophagitis in elderly patients. Consecutive gastroscopy patients were recruited. Multiple biopsies were taken from oesophagus, stomach, antrum and duodenum for histology and rapid urease tests. Patients also had IgG ELISA antibodies and 13C-urea breath tests performed. Patients with macroscopic or microscopic evidence of reflux oesophagitis were compared to patients with macroscopically normal upper gastrointestinal tracts and no microscopic evidence of reflux. A total of 114 patients were recruited, average age 78.9 years (+/- 5.4). There were 37 refluxers and 33 non-refluxers. We found no evidence for an association between the presence of H pylori and reflux oesophagitis in elderly patients. The high prevalence of H pylori in patients with reflux oesophagitis can be explained by the presence of incidental gastritis.
幽门螺杆菌与胃炎、消化性溃疡及胃恶性肿瘤有关。人们很少关注它可能在反流性食管炎发病机制中也起作用这一可能性。在那些有终生感染且为研究与该生物体相关的黏膜变化提供了理想群体的老年患者中尤其如此。本研究的目的是确定幽门螺杆菌是否与老年患者的反流性食管炎有关。招募连续的胃镜检查患者。从食管、胃、胃窦和十二指肠多处取材进行组织学检查和快速尿素酶试验。患者还进行了IgG ELISA抗体检测和¹³C - 尿素呼气试验。将有反流性食管炎宏观或微观证据的患者与上消化道宏观正常且无反流微观证据的患者进行比较。共招募了114名患者，平均年龄78.9岁（±5.4）。有37名反流患者和33名无反流患者。我们没有发现证据表明老年患者中幽门螺杆菌的存在与反流性食管炎有关。反流性食管炎患者中幽门螺杆菌的高患病率可由偶然存在的胃炎来解释。
