O'Connor H J, Cunnane K
Department of Medicine, General Hospital, Tullamore, Co. Offaly, Ireland.
Ir J Med Sci. 1994 Aug;163(8):369-73. doi: 10.1007/BF02942830.
In a prospective evaluation of the relationship between Helicobacter pylori infection and gastro-oesophageal reflux disease (GORD), 93 consecutive patients (47 female: 46 male: mean age, 46 years: range 13-93) with symptoms and endoscopic evidence of GORD were studied. A total of 50 patients (54%) were H. pylori-positive on gastric antral biopsies. No significant correlation was detected between H. pylori status and grade of oesophagitis. The prevalence of H. pylori infection showed a gradual increase with age. Of 64 patients with a hiatal hernia, 28 (44%) had histological evidence of H. pylori infection of the hernia mucosa; 27 of these patients (96%) had associated H. pylori in the gastric antrum. Of the 36 patients whose hiatal hernia was H. pylori-negative, only 6 (17%) had antral H. pylori (P < 0.001). Of the 8 patients found to have Barrett's oesophagus, only 1 had H. pylori detected on the Barrett's mucosa. Our results do not support the presence of a significant association between H. pylori infection and GORD.
在一项关于幽门螺杆菌感染与胃食管反流病（GORD）关系的前瞻性评估中，对93例有GORD症状及内镜检查证据的连续患者（47例女性，46例男性，平均年龄46岁，范围13 - 93岁）进行了研究。共有50例患者（54%）胃窦活检显示幽门螺杆菌阳性。未检测到幽门螺杆菌感染状态与食管炎分级之间存在显著相关性。幽门螺杆菌感染率随年龄逐渐升高。在64例患有食管裂孔疝的患者中，28例（44%）疝黏膜有幽门螺杆菌感染的组织学证据；其中27例（96%）胃窦部也有幽门螺杆菌感染。在36例食管裂孔疝幽门螺杆菌阴性的患者中，只有6例（17%）胃窦部有幽门螺杆菌感染（P < 0.001）。在8例发现有巴雷特食管的患者中，仅1例在巴雷特黏膜检测到幽门螺杆菌。我们的结果不支持幽门螺杆菌感染与GORD之间存在显著关联。
