Satin K P, Wong O, Yuan L A, Bailey W J, Newton K L, Wen C P, Swencicki R E
Division of Health and Medical Services, Chevron Corporation, San Francisco, Calif. 94105, USA.
J Occup Environ Med. 1996 May;38(5):492-506. doi: 10.1097/00043764-199605000-00010.
To investigate further the possible role of occupational exposures on mortality, an update of a large Texas petroleum refinery cohort was undertaken. Between 1937 and 1987, 6799 deaths were identified among 17,844 employees. Relative to the general population of Texas, the overall standardized mortality ratio (SMR) showed a statistically significant deficit, as did nine other cause-of-death categories. Statistically significant mortality excesses were found for bone cancer (SMR = 207.8: 95% confidence interval [CI], 110.6 to 355.3), acute lymphocytic leukemia (ALL) (SMR = 259.6; 95% CI, 112.1 to 511.5), and benign/unspecified neoplasms (SMR = 194.9; 95% CI, 129.5 to 281.7). However, none of these diseases demonstrated an exposure-response relationship with length of employment. Subcohort mortality analyses by sex and race groups, length of employment, interval since hire, period of hire, and pay status were also performed. Overall, the update findings do not indicate that any excess mortality occurred as a result of employment at the refinery.
为了进一步研究职业暴露对死亡率的潜在影响，我们对得克萨斯州一个大型炼油厂的队列进行了更新研究。1937年至1987年间，在17844名员工中确认了6799例死亡。与得克萨斯州的普通人群相比，总体标准化死亡率（SMR）显示出统计学上的显著不足，其他九个死因类别也是如此。在骨癌（SMR = 207.8：95%置信区间[CI]，110.6至355.3）、急性淋巴细胞白血病（ALL）（SMR = 259.6；95%CI，112.1至511.5）和良性/未明确的肿瘤（SMR = 194.9；95%CI，129.5至281.7）方面发现了统计学上显著的死亡率过高情况。然而，这些疾病均未显示出与就业时长的暴露-反应关系。我们还按性别和种族组、就业时长、入职后的间隔时间、入职时期以及薪酬状况进行了亚队列死亡率分析。总体而言，更新后的研究结果并未表明在该炼油厂工作导致了任何额外的死亡率过高情况。
