Skinner R, Appleton A L, Sprott M S, Barer M R, Magee J G, Darbyshire P J, Abinun M, Cant A J
Department of Paediatrics, Newcastle General Hospital, Newcastle-upon-Tyne, UK.
Bone Marrow Transplant. 1996 May;17(5):877-80.
An infant with severe combined immunodeficiency (SCID) is described, who presented with severe anaemia and hepatosplenomegaly due to disseminated Bacillus Calmette-Guérin (BCG) infection involving the bone marrow, liver and spleen. After BMT, huge splenic enlargement occurred, presumably due to proliferation of engrafted donor lymphocytes, leading to severe hypersplenism. Peripheral blood cell consumption was resolved by splenectomy, but gradual loss of the marrow graft followed.
本文描述了一名患有严重联合免疫缺陷（SCID）的婴儿，该婴儿因播散性卡介苗（BCG）感染累及骨髓、肝脏和脾脏而出现严重贫血和肝脾肿大。骨髓移植后，脾脏出现巨大肿大，推测是由于植入的供体淋巴细胞增殖，导致严重脾功能亢进。脾切除术后外周血细胞消耗问题得到解决，但随后骨髓移植物逐渐丢失。
