O'Shea D, Gunn I, Chen X, Bloom S, Herbert J
Division of Endocrinology, Royal Postgraduate Medical School, London, UK.
Neuroreport. 1996 Feb 29;7(3):830-2. doi: 10.1097/00001756-199602290-00035.
We have already established that central glucagon-like peptide-1 (GLP-1) has a role in the central control of food intake. In this study, experiments were conducted to establish the effect of acute intraperitoneal (i.p.) and intracerebroventricular (i.c.v.) administration of GLP-1 on temperature. Injection of 10 micrograms GLP-1 i.c.v. caused a significant reduction in temperature over the subsequent 2 h and reduced food intake as expected. Both effects were blocked by prior i.c.v. administration of the GLP-1 antagonist exendin 9-39 at a ratio of 30:1. Administration of 300 micrograms GLP-1 i.p. also reduced temperature over the 2 h following injection but had no effect on food intake. Administration of exendin 9-39 alone by the i.c.v. route had no effect on temperature. These results indicate that GLP-1 is a neuropeptide involved in the regulation of temperature. Furthermore, the mechanisms that mediate the effect on temperature may be different from those regulating food intake given the effect on temperature but not food intake of i.p. GLP-1.
我们已经确定中枢胰高血糖素样肽-1（GLP-1）在食物摄入的中枢控制中发挥作用。在本研究中，进行了实验以确定腹腔内（i.p.）和脑室内（i.c.v.）急性注射GLP-1对体温的影响。脑室内注射10微克GLP-1在随后的2小时内导致体温显著降低，并如预期那样减少了食物摄入量。这两种效应均被预先以30:1的比例脑室内注射GLP-1拮抗剂艾塞那肽9-39所阻断。腹腔注射300微克GLP-1在注射后的2小时内也降低了体温，但对食物摄入量没有影响。单独通过脑室内途径注射艾塞那肽9-39对体温没有影响。这些结果表明GLP-1是一种参与体温调节的神经肽。此外，鉴于腹腔注射GLP-1对体温而非食物摄入量有影响，介导对体温影响的机制可能与调节食物摄入的机制不同。
