Kendell R E, Juszczak E, Cole S K
University of Edinburgh.
Br J Psychiatry. 1996 May;168(5):556-61. doi: 10.1192/bjp.168.5.556.
There have been many reports of a higher incidence of 'obstetric complications' in the histories of schizophrenics than of controls, but because of the methodological shortcomings of most of these comparisons the relationship remains controversial.
Comprehensive records covering all psychiatric hospital admissions and all hospital deliveries in Scotland since 1971 made it possible to identify the obstetric records of people born in 1971-74 who were subsequently admitted to hospital with a diagnosis of schizophrenia, and then to compare their standardised obstetric records with those of closely matched controls.
One hundred and fifteen schizophrenic/control pairs were compared. The former showed a highly significant (P < 0.001) excess of complications of both pregnancy and delivery. In particular, there was a significant excess of pre-eclampsia (10 v. 2) and of infants detained in hospital for neonatal care (18 v. 6).
The raised incidence of obstetric complications often reported in people with schizophrenia is genuine and probably contributes to the aetiology of the condition.
有许多报告指出，精神分裂症患者病史中“产科并发症”的发生率高于对照组，但由于大多数此类比较存在方法学上的缺陷，这种关系仍存在争议。
涵盖自1971年以来苏格兰所有精神病院入院病例和所有医院分娩情况的综合记录，使得确定1971 - 1974年出生、随后因精神分裂症诊断而入院的人群的产科记录成为可能，进而将他们的标准化产科记录与匹配度高的对照组进行比较。
比较了115对精神分裂症患者/对照。前者在妊娠和分娩并发症方面均显示出极显著（P < 0.001）的过量。特别是，子痫前期（10例对2例）和因新生儿护理而住院的婴儿（18例对6例）有显著过量。
精神分裂症患者中经常报告的产科并发症发生率升高是真实的，可能对该病的病因学有影响。
