Sacker A, Done D J, Crow T J
Department of Psychiatry, University of Oxford.
Psychol Med. 1996 Mar;26(2):279-87. doi: 10.1017/s003329170003467x.
On the basis of previous findings, we used meta-analyses to consider whether births to parents with schizophrenia have an increased risk of obstetric complications. Meta-analyses were based on published studies satisfying the following selection criteria. The schizophrenic diagnosis could apply to either parent: parents with non-schizophrenic psychoses were not included: only normal controls were accepted. In all, 14 studies provided effect sizes or data from which these could be derived. Studies were identified by data searches through MEDLINE, PSYCLIT and through references of papers relating to the subject. Births to individuals with schizophrenia incur an increased risk of pregnancy and birth complications, low birthweight and poor neonatal condition. However, in each case the effect size is small (mean r = 0.155; 95% CI = 0.057). The risk is greater for mothers with schizophrenia and is not confined to mothers with onset pre-delivery or to the births of the children who become schizophrenic themselves.
基于先前的研究结果，我们进行了荟萃分析，以探讨父母患有精神分裂症的孩子出现产科并发症的风险是否增加。荟萃分析基于符合以下选择标准的已发表研究。精神分裂症诊断可适用于父母双方中的任何一方：患有非精神分裂症性精神病的父母不包括在内：仅接受正常对照。共有14项研究提供了效应量或可从中得出效应量的数据。通过检索MEDLINE、PSYCLIT以及相关主题论文的参考文献来识别研究。精神分裂症患者生育时出现妊娠和分娩并发症、低出生体重以及新生儿状况不佳的风险增加。然而，在每种情况下，效应量都很小（平均r = 0.155；95%置信区间 = 0.057）。患有精神分裂症的母亲风险更大，且不仅限于分娩前发病的母亲或其孩子自身会患精神分裂症的分娩情况。
