Kirov G, Jones P B, Harvey I, Lewis S W, Toone B K, Rifkin L, Sham P, Murray R M
Department of Psychological Medicine, Institute of Psychiatry, London, UK.
Schizophr Res. 1996 May;20(1-2):117-24. doi: 10.1016/0920-9964(95)00063-1.
We compared the age at onset of 184 patients with functional psychoses with and without a history of obstetric complications (OCs) as defined by the scale of Lewis et al. (1989). OCs had no significant influence on the age at onset in those patients who had affective psychoses or were non-white. There were 73 white patients with a DSM-III-R diagnosis of schizophrenia. The mean age at onset of those 25 who had a history of at least one definite OC was 2.6 years earlier than that of the 48 patients with no history of OCs. This effect was entirely due to the male patients with histories of OCs who had, on average, a 3.5 years earlier age at onset. There were no gender differences in age at onset among schizophrenics without a history of OCs. We suggest that a subgroup of male patients with a history of OCs is responsible for the earlier age at onset in male compared to female schizophrenics.
我们比较了184例功能性精神病患者的起病年龄，这些患者根据刘易斯等人（1989年）的量表定义，分为有产科并发症（OCs）病史和无产科并发症病史两组。OCs对患有情感性精神病或非白人的患者的起病年龄没有显著影响。有73例白人患者被诊断为DSM-III-R精神分裂症。在这73例患者中，有25例至少有一次明确的OCs病史，其平均起病年龄比48例无OCs病史的患者早2.6岁。这种影响完全是由于有OCs病史的男性患者，他们的平均起病年龄早3.5岁。无OCs病史的精神分裂症患者在起病年龄上没有性别差异。我们认为，有OCs病史的男性患者亚组是导致男性精神分裂症患者比女性患者起病年龄更早的原因。
