非典型抗精神病药物体内结合特性的正电子发射断层扫描。D2和5-HT2受体占有率研究及临床反应综述。 - Suppr

Suppr

超能文献

Positron emission tomography of in-vivo binding characteristics of atypical antipsychotic drugs. Review of D2 and 5-HT2 receptor occupancy studies and clinical response.

作者信息

Nyberg S, Nakashima Y, Nordström A L, Halldin C, Farde L

机构信息

Department of Clinical Neuroscience, Karolinska Hospital, Stockholm, Sweden.

出版信息

Br J Psychiatry Suppl. 1996 May(29):40-4.

PMID:8733822

Abstract

摘要

相似文献

Positron emission tomography of in-vivo binding characteristics of atypical antipsychotic drugs. Review of D2 and 5-HT2 receptor occupancy studies and clinical response.非典型抗精神病药物体内结合特性的正电子发射断层扫描。D2和5-HT2受体占有率研究及临床反应综述。

Br J Psychiatry Suppl. 1996 May(29):40-4.

Clinical and theoretical implications of 5-HT2 and D2 receptor occupancy of clozapine, risperidone, and olanzapine in schizophrenia.氯氮平、利培酮和奥氮平对5-HT2和D2受体的占据在精神分裂症中的临床及理论意义。

Am J Psychiatry. 1999 Feb;156(2):286-93. doi: 10.1176/ajp.156.2.286.

Positron emission tomography studies on D2 and 5-HT2 receptor binding in risperidone-treated schizophrenic patients.对接受利培酮治疗的精神分裂症患者的D2和5-HT2受体结合情况进行的正电子发射断层扫描研究。

J Clin Psychopharmacol. 1995 Feb;15(1 Suppl 1):19S-23S. doi: 10.1097/00004714-199502001-00004.

A new framework for investigating antipsychotic action in humans: lessons from PET imaging.一种研究人类抗精神病药物作用的新框架：正电子发射断层扫描成像的经验教训。

Mol Psychiatry. 1998 Mar;3(2):135-40. doi: 10.1038/sj.mp.4000327.

Am J Psychiatry. 1999 Jun;156(6):869-75. doi: 10.1176/ajp.156.6.869.

5-HT2 and D2 receptor occupancy of olanzapine in schizophrenia: a PET investigation.奥氮平对精神分裂症患者5-HT2和D2受体的占有率：一项正电子发射断层扫描（PET）研究

Am J Psychiatry. 1998 Jul;155(7):921-8. doi: 10.1176/ajp.155.7.921.

Equivalent occupancy of dopamine D1 and D2 receptors with clozapine: differentiation from other atypical antipsychotics.氯氮平对多巴胺D1和D2受体的等效占有率：与其他非典型抗精神病药物的区别

Am J Psychiatry. 2004 Sep;161(9):1620-5. doi: 10.1176/appi.ajp.161.9.1620.

Iodine-123-iodobenzamide SPECT assessment of dopamine D2 receptor occupancy in riperidone-treated schizophrenic patients.碘-123-碘苯甲酰胺单光子发射计算机断层扫描评估利培酮治疗的精神分裂症患者多巴胺D2受体占有率

J Nucl Med. 1998 Jul;39(7):1138-42.

Does fast dissociation from the dopamine d(2) receptor explain the action of atypical antipsychotics?: A new hypothesis.从多巴胺D(2)受体的快速解离能否解释非典型抗精神病药物的作用？：一个新假说。

Am J Psychiatry. 2001 Mar;158(3):360-9. doi: 10.1176/appi.ajp.158.3.360.

A positron emission tomography study of quetiapine in schizophrenia: a preliminary finding of an antipsychotic effect with only transiently high dopamine D2 receptor occupancy.一项关于喹硫平治疗精神分裂症的正电子发射断层扫描研究：仅短暂性高多巴胺D2受体占有率的抗精神病作用的初步发现。

Arch Gen Psychiatry. 2000 Jun;57(6):553-9. doi: 10.1001/archpsyc.57.6.553.

引用本文的文献

Preferential binding to dopamine D3 over D2 receptors by cariprazine in patients with schizophrenia using PET with the D3/D2 receptor ligand [(11)C]-(+)-PHNO.在精神分裂症患者中，使用D3/D2受体配体[(11)C]-(+)-PHNO的PET研究显示，卡立普唑对多巴胺D3受体的结合优于D2受体。

Psychopharmacology (Berl). 2016 Oct;233(19-20):3503-12. doi: 10.1007/s00213-016-4382-y. Epub 2016 Aug 15.

Occupancy of dopamine D₂ and D₃ and serotonin 5-HT₁A receptors by the novel antipsychotic drug candidate, cariprazine (RGH-188), in monkey brain measured using positron emission tomography.使用正电子发射断层扫描术测量新型抗精神病候选药物卡利拉嗪（RGH-188）在猴脑中对多巴胺 D₂ 和 D₃ 以及 5-羟色胺 5-HT₁A 受体的占有率。

Psychopharmacology (Berl). 2011 Dec;218(3):579-87. doi: 10.1007/s00213-011-2343-z. Epub 2011 May 28.

Subnanomolar dopamine D3 receptor antagonism coupled to moderate D2 affinity results in favourable antipsychotic-like activity in rodent models: I. neurochemical characterisation of RG-15.亚纳摩尔级多巴胺D3受体拮抗作用与适度的D2亲和力相结合，在啮齿动物模型中产生了良好的抗精神病样活性：I. RG-15的神经化学特征

Naunyn Schmiedebergs Arch Pharmacol. 2008 Nov;378(5):515-28. doi: 10.1007/s00210-008-0308-5. Epub 2008 Jun 13.

Subnanomolar dopamine D3 receptor antagonism coupled to moderate D2 affinity results in favourable antipsychotic-like activity in rodent models: II. behavioural characterisation of RG-15.亚纳摩尔级多巴胺D3受体拮抗作用与适度的D2亲和力相结合，在啮齿动物模型中产生了良好的类抗精神病活性：II. RG-15的行为特征

Naunyn Schmiedebergs Arch Pharmacol. 2008 Nov;378(5):529-39. doi: 10.1007/s00210-008-0311-x. Epub 2008 Jun 12.

Conventional and atypical antipsychotics in the elderly : a review.老年人的传统和非典型抗精神病药物：综述。

Clin Drug Investig. 2003;23(5):287-322. doi: 10.2165/00044011-200323050-00001.

Occupancy of dopamine D(1), D (2) and serotonin (2A) receptors in schizophrenic patients treated with flupentixol in comparison with risperidone and haloperidol.与利培酮和氟哌啶醇相比，氟哌噻吨治疗的精神分裂症患者中多巴胺D(1)、D(2)和5-羟色胺(2A)受体的占有率

Psychopharmacology (Berl). 2007 Feb;190(2):241-9. doi: 10.1007/s00213-006-0611-0. Epub 2006 Nov 17.

Central nervous system drug development: an integrative biomarker approach toward individualized medicine.中枢神经系统药物研发：迈向个体化医疗的综合生物标志物方法。

NeuroRx. 2005 Oct;2(4):683-95. doi: 10.1602/neurorx.2.4.683.

First- and second-generation antipsychotic medication and cognitive processing in schizophrenia.第一代和第二代抗精神病药物与精神分裂症的认知加工

Curr Psychiatry Rep. 2005 Aug;7(4):304-10. doi: 10.1007/s11920-005-0085-5.

A positron emission tomography (PET) study of cerebral dopamine D2 and serotonine 5-HT2A receptor occupancy in patients treated with cyamemazine (Tercian).一项关于接受氰美马嗪（特西铵）治疗的患者大脑中多巴胺 D2 和 5-羟色胺 5-HT2A 受体占有率的正电子发射断层扫描（PET）研究。

Psychopharmacology (Berl). 2005 Jul;180(2):377-84. doi: 10.1007/s00213-005-2172-z. Epub 2005 Mar 15.

Neurotensin-deficient mice show altered responses to antipsychotic drugs.缺乏神经降压素的小鼠对抗精神病药物的反应发生改变。

Proc Natl Acad Sci U S A. 2001 Jul 3;98(14):8048-53. doi: 10.1073/pnas.141042198. Epub 2001 Jun 26.

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型，支持多种主流文档格式。

立即体验