Hauser E, Freilinger M, Seidl R, Groh C
Department of Pediatrics, University of Vienna, Austria.
J Child Neurol. 1996 May;11(3):201-4. doi: 10.1177/088307389601100307.
The aim of this study was to investigate the prognosis of childhood epilepsy and to analyze prognostic factors in addition to remission rate in a follow-up of newly referred patients. Two hundred eighty-one patients were followed for a mean period of 5.3 years. Overall, 253 patients (90%) achieved 1-year remission. The beginning of a 1-year seizure-free period was achieved in 77.9% by 1 year, in 84% by 2 years and in 88.6% by 3 years after onset of treatment. Early onset of seizures, symptomatic etiology, and neurologic handicap predicted a worse prognosis. In 44 of 253 children with complete suppression of seizures for 1 year, relapses occurred within the follow-up period. In one child with a relapse, remission could not be achieved in the 2nd year thereafter. In conclusion, our study shows a good prognosis for most children with epilepsy, especially in patients with idiopathic epilepsy and late onset of seizures and without neurologic dysfunction. Moreover, our data strongly suggest that the long-term pattern of seizure control is largely established during the first 2 years of treatment.
本研究的目的是调查儿童癫痫的预后情况，并在对新转诊患者的随访中分析除缓解率之外的预后因素。281例患者接受了平均5.3年的随访。总体而言，253例患者（90%）实现了1年缓解。治疗开始后1年时，77.9%的患者进入了1年无癫痫发作期，2年时为84%，3年时为88.6%。癫痫发作早发、症状性病因和神经功能障碍预示预后较差。在253例癫痫发作完全抑制达1年的儿童中，有44例在随访期内复发。在1例复发儿童中，其后第2年未能实现缓解。总之，我们的研究表明，大多数癫痫儿童预后良好，尤其是特发性癫痫、癫痫发作晚发且无神经功能障碍的患者。此外，我们的数据强烈表明，癫痫控制的长期模式在治疗的前2年基本确立。
