[静脉炎后疾病所揭示的对活化蛋白C的抵抗。两例病例]
[Resistance to activated protein C disclosed by postphlebitic disease. Two cases].
作者信息
Foueré S, Lestang P, Cosnes A, Gouault-Heilmann M, Revuz J
机构信息
Service de Dermatologie, Hôpital Henri-Mondor, Créteil.
出版信息
Ann Dermatol Venereol. 1996;123(1):24-5.
INTRODUCTION
Recently, resistance to activated protein C has been discovered. Resistance to activated protein C appears to be the main cause of familial thrombosis.
CASE REPORT
Two consecutive patients have been studied. Both have a venous insufficiency associated with eczema in one patient and venous ulceration in the second patient. The two patients had a personal and familial history of venous thrombosis. In both patients, a resistance to activated protein C was found associated with a mutation in the factor V gene in residue 506.
DISCUSSION
When a personal or familial history of the venous thrombosis is associated with symptoms of venous insufficiency, resistance to activated protein C must be added to the search for proteins C, S and anti-thrombin III deficiency.
引言
最近，发现了对活化蛋白C的抵抗现象。对活化蛋白C的抵抗似乎是家族性血栓形成的主要原因。
病例报告
对两名连续的患者进行了研究。其中一名患者有静脉功能不全并伴有湿疹，另一名患者有静脉溃疡。这两名患者都有静脉血栓形成的个人和家族病史。在两名患者中，均发现对活化蛋白C的抵抗与因子V基因第506位残基的突变有关。
讨论
当静脉血栓形成的个人或家族病史与静脉功能不全的症状相关时，在寻找蛋白C、蛋白S和抗凝血酶III缺乏症时，必须考虑对活化蛋白C的抵抗。
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