Chancerelle Y
Unité de Radiobiochimie, Centre de Recherches du Service de Santé des Armées, La Tronche.
Ann Pharm Fr. 1996;54(2):60-3.
Malondialdehyde (MDA), a lipid peroxidation product, reacts with free amino groups of proteins to give amino-3-iminopropene (AIP) bridges which are immunogenic. Antibodies reacting specifically with MDA-crosslinked proteins preexist in the sera of healthy human subjects, and we hypothesize that they are implicated in processes of senescent cells recognition and elimination. Results obtained by immunofluorescence and flow cytometry show an immunological response against structures arising on cell membranes from MDA reaction with free amino groups of proteins. Such structures might also be implicated in autoimmunity.
丙二醛（MDA）是一种脂质过氧化产物，它与蛋白质的游离氨基反应生成具有免疫原性的氨基-3-亚氨基丙烯（AIP）桥。在健康人类受试者的血清中预先存在与MDA交联蛋白特异性反应的抗体，我们推测它们参与了衰老细胞的识别和清除过程。通过免疫荧光和流式细胞术获得的结果显示，针对MDA与蛋白质游离氨基反应在细胞膜上产生的结构存在免疫反应。这些结构也可能与自身免疫有关。
