Grillot R, Mondon P, Brenier M P, Ambroise-Thomas P
Département de Parasitologie-Mycologie Médicale et Moléculaire, CNRS EP 78, Université Joseph-Fourier Grenoble I, La Tronche.
Ann Pharm Fr. 1996;54(2):68-72.
During the last two decades, deep changes have arised in aspergillosis. Thus, this fungal infection mainly due Aspergillus fumigatus is becoming a serious public health-hazard in the growing population of immunocompromised patients. From literature and their own experience, the authors present a synthesis of phenomenons promoting this evolution: the host predisposing factors, environment and potential contamination sources, then the fungus itself. Genetic research developed into the disease-causing organism could be of major interest in epidemiology of aspergillosis and to identify new targets of prophylaxis.
在过去二十年中，曲霉病发生了深刻变化。因此，这种主要由烟曲霉引起的真菌感染在免疫功能低下患者不断增加的人群中正在成为一种严重的公共卫生危害。作者根据文献和自身经验，对促成这种演变的现象进行了综述：宿主易感因素、环境和潜在污染源，以及真菌本身。对致病生物体开展的基因研究可能对曲霉病流行病学及确定新的预防靶点具有重要意义。
